When you have 2 upsets in round 1, the math says you'll get 25 when you add the seeds in round 2. This is the first time in history we've seen a 9 and a 16 of course, but there have been multiple 12 vs 13s and 11 vs 14s.
Year Winner Loser Score
2013 (13) La Salle (12) Mississippi 76–74
2012 (13) Ohio (12) South Florida 62–56
1998 (13) Valparaiso (12) Florida State 83–77 (OT)
2011 (12) Richmond (13) Morehead State 65–48
2009 (12) Arizona (13) Cleveland State 71–57
2008 (12) Western Kentucky (13) San Diego 72–63
2008 (12) Villanova (13) Siena 84–72
2001 (12) Gonzaga (13) Indiana State 85–68
1993 (12) George Washington (13) Southern 90–80
1992 (12) New Mexico State (13) Southwestern Louisiana 81–73
1991 (12) Eastern Michigan (13) Penn State 71–68 (OT)
2015 (11) UCLA (14) UAB 92–75
2014 (11) Tennessee (14) Mercer 83–63
1998 (11) Washington (14) Richmond 81–66
1991 (11) Connecticut (14) Xavier 66–50
1989 (11) Minnesota (14) Siena 80–67
Notable; 12s typically beat 13s and 11s have always destroyed 14s in round 2.
Year Winner Loser Score
2013 (13) La Salle (12) Mississippi 76–74
2012 (13) Ohio (12) South Florida 62–56
1998 (13) Valparaiso (12) Florida State 83–77 (OT)
2011 (12) Richmond (13) Morehead State 65–48
2009 (12) Arizona (13) Cleveland State 71–57
2008 (12) Western Kentucky (13) San Diego 72–63
2008 (12) Villanova (13) Siena 84–72
2001 (12) Gonzaga (13) Indiana State 85–68
1993 (12) George Washington (13) Southern 90–80
1992 (12) New Mexico State (13) Southwestern Louisiana 81–73
1991 (12) Eastern Michigan (13) Penn State 71–68 (OT)
2015 (11) UCLA (14) UAB 92–75
2014 (11) Tennessee (14) Mercer 83–63
1998 (11) Washington (14) Richmond 81–66
1991 (11) Connecticut (14) Xavier 66–50
1989 (11) Minnesota (14) Siena 80–67
Notable; 12s typically beat 13s and 11s have always destroyed 14s in round 2.